Medical

Abiraterone May Be More Effective in Black Men With Prostate Cancer

Abiraterone May Be More Effective in Black Men With Prostate Cancer

African-American men with advanced prostate cancer might be more responsive than white men to an anti-androgen drug and steroids, according to a study led by Duke Cancer Institute researchers.

He added: "These are unbelievable results, and these are men whose cancers had all the treatments, they had everything possible, they've got no treatments left, and they are in trouble".

Results of a new clinical trial showed that men with untreatable prostate cancer may halt the spread of the disease and live longer though immunotherapy treatment. As a result, the stimulated immune system recognizes and fights the cancer cells present in the body.

In the study involving 258 men with an advanced form of prostate cancer, researchers found that men lived much longer when they were treated with the immunotherapy drug pembrolizumab.

Nonetheless, for sufferers reminiscent of these within the new examine with docetaxel-refractory metastatic castration-resistant prostate most cancers, there may be at present no efficient therapy.

Immunotherapy, which personalizes treatment based on the genetic make-up of tumors, is only successful for a minority of patients, professor Paul Workman, chief executive of the ICR, said in a statement. The amount of damage that a cell can endure, however, is influenced by external factors such as alcohol, smoking, exposure to UV light, and many cancer cells have lost some of the ability to self-repair the genome.




While only 5% of men in the trial saw their tumours shrink or disappear after treatment, many of those had mutations in genes involved in repairing DNA in their tumours.

They stop cancers turning off the immune system so the body can keep on attacking the tumour.

Researcher Professor Johann de Bono commented on the findings: "This is the first evidence that a subset of prostate cancer patients do spectacularly well on immunotherapy".

Data from some other cancer types, such as bowel, has similarly shown tumours with defects in DNA fix mutations are more susceptible to immunotherapy.

"It's exciting that immunotherapy could offer some men more time with their loved ones where they have such advanced disease that they have run out of existing treatment options". It seems to work incredibly well for a handful of patients, have a temporary effect in others, and do nothing for the rest.

However, the therapy will not work for most patients. He added: 'The next stage is to try and develop tests to help us better identify which patients will benefit most'. "This new trial has found that testing for mutations in DNA fix genes could be valuable marker of who will respond".


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